Update on tumor-infiltrating lymphocytes (TILs) in breast cancer, including recommendations to assess TILs in residual disease after neoadjuvant therapy and in carcinoma in situ: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer.
Identifieur interne : 000102 ( Main/Exploration ); précédent : 000101; suivant : 000103Update on tumor-infiltrating lymphocytes (TILs) in breast cancer, including recommendations to assess TILs in residual disease after neoadjuvant therapy and in carcinoma in situ: A report of the International Immuno-Oncology Biomarker Working Group on Breast Cancer.
Auteurs : Maria Vittoria Dieci [Italie] ; Nina Radosevic-Robin [France] ; Susan Fineberg [États-Unis] ; Gert Van Den Eynden [Belgique] ; Nils Ternes [France] ; Frederique Penault-Llorca [France] ; Giancarlo Pruneri [Italie] ; Timothy M. D'Alfonso [États-Unis] ; Sandra Demaria [États-Unis] ; Carlos Castaneda [Pérou] ; Joselyn Sanchez [Pérou] ; Sunil Badve [États-Unis] ; Stefan Michiels [France] ; Veerle Bossuyt [États-Unis] ; Federico Rojo [Espagne] ; Baljit Singh [États-Unis] ; Torsten Nielsen [Canada] ; Giuseppe Viale [Italie] ; Seong-Rim Kim [États-Unis] ; Stephen Hewitt [États-Unis] ; Stephan Wienert [Allemagne] ; Sybille Loibl [Allemagne] ; David Rimm [États-Unis] ; Fraser Symmans [États-Unis] ; Carsten Denkert [Allemagne] ; Sylvia Adams [États-Unis] ; Sherene Loi [Australie] ; Roberto Salgado [Belgique]Source :
- Seminars in cancer biology [ 1096-3650 ] ; 2017.
Abstract
Morphological evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer is gaining momentum as evidence strengthens the clinical relevance of this immunological biomarker. TILs in the post-neoadjuvant residual disease setting are acquiring increasing importance as a stratifying marker in clinical trials, considering the raising interest on immunotherapeutic strategies after neoadjuvant chemotherapy. TILs in ductal carcinoma in situ, with or without invasive carcinoma, represent an emerging area of clinical breast cancer research. The aim of this report is to update pathologists, clinicians and researchers on TIL assessment in both the post-neoadjuvant residual disease and the ductal carcinoma in situ settings. The International Immuno-Oncology Working Group proposes a method for assessing TILs in these settings, based on the previously published International Guidelines on TIL Assessment in Breast Cancer. In this regard, these recommendations represent a consensus guidance for pathologists, aimed to achieve the highest possible consistency among future studies.
DOI: 10.1016/j.semcancer.2017.10.003
PubMed: 29024776
Affiliations:
- Allemagne, Australie, Belgique, Canada, Espagne, France, Italie, Pérou, États-Unis
- Auvergne (région administrative), Auvergne-Rhône-Alpes, Berlin, Communauté de Madrid, Lombardie, Maryland, Pennsylvanie, Région de Bruxelles-Capitale, Texas, Victoria (État), État de New York
- Berlin, Bruxelles, Clermont-Ferrand, Houston, Madrid, Melbourne, Milan
- Université libre de Bruxelles
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Neu-Isenburg</wicri:regionArea><wicri:noRegion>Neu-Isenburg</wicri:noRegion><wicri:noRegion>Neu-Isenburg</wicri:noRegion><wicri:noRegion>Neu-Isenburg</wicri:noRegion></affiliation></author><author><name sortKey="Rimm, David" sort="Rimm, David" uniqKey="Rimm D" first="David" last="Rimm">David Rimm</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Yale University School of Medicine, New Haven, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Yale University School of Medicine, New Haven</wicri:regionArea><wicri:noRegion>New Haven</wicri:noRegion></affiliation></author><author><name sortKey="Symmans, Fraser" sort="Symmans, Fraser" uniqKey="Symmans F" first="Fraser" last="Symmans">Fraser Symmans</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston</wicri:regionArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Denkert, Carsten" sort="Denkert, Carsten" uniqKey="Denkert C" first="Carsten" last="Denkert">Carsten Denkert</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Charité Universitätsmedizin Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Adams, Sylvia" sort="Adams, Sylvia" uniqKey="Adams S" first="Sylvia" last="Adams">Sylvia Adams</name><affiliation wicri:level="2"><nlm:affiliation>New York University Medical School, Perlmutter Cancer Center, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York University Medical School, Perlmutter Cancer Center, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Loi, Sherene" sort="Loi, Sherene" uniqKey="Loi S" first="Sherene" last="Loi">Sherene Loi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Salgado, Roberto" sort="Salgado, Roberto" uniqKey="Salgado R" 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of the International Immuno-Oncology Biomarker Working Group on Breast Cancer.</title><author><name sortKey="Dieci, Maria Vittoria" sort="Dieci, Maria Vittoria" uniqKey="Dieci M" first="Maria Vittoria" last="Dieci">Maria Vittoria Dieci</name><affiliation wicri:level="1"><nlm:affiliation>Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy; Medical Oncology 2, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy. Electronic address: mariavittoriadieci@gmail.com.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy; Medical Oncology 2, Veneto Institute of Oncology IOV - IRCCS, Padua</wicri:regionArea><wicri:noRegion>Padua</wicri:noRegion></affiliation></author><author><name sortKey="Radosevic Robin, Nina" sort="Radosevic Robin, Nina" uniqKey="Radosevic Robin N" first="Nina" last="Radosevic-Robin">Nina Radosevic-Robin</name><affiliation wicri:level="3"><nlm:affiliation>Department of Surgical Pathology and Biopathology, Jean Perrin Comprehensive Cancer Centre, Clermont-Ferrand, France; Inserm/University of Auvergne U1240, Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Surgical Pathology and Biopathology, Jean Perrin Comprehensive Cancer Centre, Clermont-Ferrand, France; Inserm/University of Auvergne U1240, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Fineberg, Susan" sort="Fineberg, Susan" uniqKey="Fineberg S" first="Susan" last="Fineberg">Susan Fineberg</name><affiliation wicri:level="2"><nlm:affiliation>Montefiore Medical Center, Bronx, NY, USA; The Albert Einstein College of Medicine, Bronx, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Montefiore Medical Center, Bronx, NY, USA; The Albert Einstein College of Medicine, Bronx, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Van Den Eynden, Gert" sort="Van Den Eynden, Gert" uniqKey="Van Den Eynden G" first="Gert" last="Van Den Eynden">Gert Van Den Eynden</name><affiliation wicri:level="4"><nlm:affiliation>Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium; Department of Pathology, GZA Ziekenhuizen, Antwerp, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Molecular Immunology Unit, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium; Department of Pathology, GZA Ziekenhuizen, Antwerp</wicri:regionArea><orgName type="university">Université libre de Bruxelles</orgName><placeName><settlement type="city">Bruxelles</settlement><region type="region" nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Ternes, Nils" sort="Ternes, Nils" uniqKey="Ternes N" first="Nils" last="Ternes">Nils Ternes</name><affiliation wicri:level="1"><nlm:affiliation>Service de Biostatistique et d'Epidémiologie, Gustave Roussy, B2 M, RdC,114 rue Edouard-Vaillant, 94805, Villejuif, France; CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, 94805, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Biostatistique et d'Epidémiologie, Gustave Roussy, B2 M, RdC,114 rue Edouard-Vaillant, 94805, Villejuif, France; CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, 94805</wicri:regionArea><wicri:noRegion>94805</wicri:noRegion><wicri:noRegion>94805</wicri:noRegion></affiliation></author><author><name sortKey="Penault Llorca, Frederique" sort="Penault Llorca, Frederique" uniqKey="Penault Llorca F" first="Frederique" last="Penault-Llorca">Frederique Penault-Llorca</name><affiliation wicri:level="3"><nlm:affiliation>Department of Surgical Pathology and Biopathology, Jean Perrin Comprehensive Cancer Centre, Clermont-Ferrand, France; Inserm/University of Auvergne U1240, Clermont-Ferrand, France; School of Medicine, University of Auvergne, Clermont-Ferrand, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Surgical Pathology and Biopathology, Jean Perrin Comprehensive Cancer Centre, Clermont-Ferrand, France; Inserm/University of Auvergne U1240, Clermont-Ferrand, France; School of Medicine, University of Auvergne, Clermont-Ferrand</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Auvergne (région administrative)</region><settlement type="city">Clermont-Ferrand</settlement></placeName></affiliation></author><author><name sortKey="Pruneri, Giancarlo" sort="Pruneri, Giancarlo" uniqKey="Pruneri G" first="Giancarlo" last="Pruneri">Giancarlo Pruneri</name><affiliation wicri:level="3"><nlm:affiliation>Division of Pathology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; University of Milan, School of Medicine, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Division of Pathology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; University of Milan, School of Medicine, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="D Alfonso, Timothy M" sort="D Alfonso, Timothy M" uniqKey="D Alfonso T" first="Timothy M" last="D'Alfonso">Timothy M. D'Alfonso</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Demaria, Sandra" sort="Demaria, Sandra" uniqKey="Demaria S" first="Sandra" last="Demaria">Sandra Demaria</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Oncology, Weill Cornell Medicine, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Castaneda, Carlos" sort="Castaneda, Carlos" uniqKey="Castaneda C" first="Carlos" last="Castaneda">Carlos Castaneda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Research, Instituto Nacional de Enfermedades Neoplasicas, Lima 15038, Peru.</nlm:affiliation><country xml:lang="fr">Pérou</country><wicri:regionArea>Department of Research, Instituto Nacional de Enfermedades Neoplasicas, Lima 15038</wicri:regionArea><wicri:noRegion>Lima 15038</wicri:noRegion></affiliation></author><author><name sortKey="Sanchez, Joselyn" sort="Sanchez, Joselyn" uniqKey="Sanchez J" first="Joselyn" last="Sanchez">Joselyn Sanchez</name><affiliation wicri:level="1"><nlm:affiliation>Department of Research, Instituto Nacional de Enfermedades Neoplasicas, Lima 15038, Peru.</nlm:affiliation><country xml:lang="fr">Pérou</country><wicri:regionArea>Department of Research, Instituto Nacional de Enfermedades Neoplasicas, Lima 15038</wicri:regionArea><wicri:noRegion>Lima 15038</wicri:noRegion></affiliation></author><author><name sortKey="Badve, Sunil" sort="Badve, Sunil" uniqKey="Badve S" first="Sunil" last="Badve">Sunil Badve</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Laboratory, Medicine, Indiana University, Indianapolis, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Laboratory, Medicine, Indiana University, Indianapolis</wicri:regionArea><wicri:noRegion>Indianapolis</wicri:noRegion></affiliation></author><author><name sortKey="Michiels, Stefan" sort="Michiels, Stefan" uniqKey="Michiels S" first="Stefan" last="Michiels">Stefan Michiels</name><affiliation wicri:level="1"><nlm:affiliation>Service de Biostatistique et d'Epidémiologie, Gustave Roussy, B2 M, RdC,114 rue Edouard-Vaillant, 94805, Villejuif, France; CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, 94805, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Biostatistique et d'Epidémiologie, Gustave Roussy, B2 M, RdC,114 rue Edouard-Vaillant, 94805, Villejuif, France; CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, 94805</wicri:regionArea><wicri:noRegion>94805</wicri:noRegion><wicri:noRegion>94805</wicri:noRegion></affiliation></author><author><name sortKey="Bossuyt, Veerle" sort="Bossuyt, Veerle" uniqKey="Bossuyt V" first="Veerle" last="Bossuyt">Veerle Bossuyt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Yale University School of Medicine, New Haven, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Yale University School of Medicine, New Haven</wicri:regionArea><wicri:noRegion>New Haven</wicri:noRegion></affiliation></author><author><name sortKey="Rojo, Federico" sort="Rojo, Federico" uniqKey="Rojo F" first="Federico" last="Rojo">Federico Rojo</name><affiliation wicri:level="3"><nlm:affiliation>Pathology Department, IIS, Fundacion Jimenez Diaz, UAM, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Pathology Department, IIS, Fundacion Jimenez Diaz, UAM, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Singh, Baljit" sort="Singh, Baljit" uniqKey="Singh B" first="Baljit" last="Singh">Baljit Singh</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, Coney Island Hospital, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Coney Island Hospital, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Nielsen, Torsten" sort="Nielsen, Torsten" uniqKey="Nielsen T" first="Torsten" last="Nielsen">Torsten Nielsen</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Pathology Evaluation Centre, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Genetic Pathology Evaluation Centre, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver</wicri:regionArea><wicri:noRegion>Vancouver</wicri:noRegion></affiliation></author><author><name sortKey="Viale, Giuseppe" sort="Viale, Giuseppe" uniqKey="Viale G" first="Giuseppe" last="Viale">Giuseppe Viale</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Istituto Europeo di Oncologia, University of Milan, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Pathology, Istituto Europeo di Oncologia, University of Milan, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Kim, Seong Rim" sort="Kim, Seong Rim" uniqKey="Kim S" first="Seong-Rim" last="Kim">Seong-Rim Kim</name><affiliation wicri:level="2"><nlm:affiliation>National Surgical Adjuvant Breast and Bowel Project Operations Center/NRG Oncology, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>National Surgical Adjuvant Breast and Bowel Project Operations Center/NRG Oncology, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Hewitt, Stephen" sort="Hewitt, Stephen" uniqKey="Hewitt S" first="Stephen" last="Hewitt">Stephen Hewitt</name><affiliation wicri:level="2"><nlm:affiliation>Experimental Pathology Laboratory, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Experimental Pathology Laboratory, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Wienert, Stephan" sort="Wienert, Stephan" uniqKey="Wienert S" first="Stephan" last="Wienert">Stephan Wienert</name><affiliation wicri:level="1"><nlm:affiliation>dlw Laborsoftware UG (haftungsbeschränkt) Lübben, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>dlw Laborsoftware UG (haftungsbeschränkt) Lübben</wicri:regionArea></affiliation></author><author><name sortKey="Loibl, Sybille" sort="Loibl, Sybille" uniqKey="Loibl S" first="Sybille" last="Loibl">Sybille Loibl</name><affiliation wicri:level="1"><nlm:affiliation>German Breast Group, Neu-Isenburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Breast Group, Neu-Isenburg</wicri:regionArea><wicri:noRegion>Neu-Isenburg</wicri:noRegion><wicri:noRegion>Neu-Isenburg</wicri:noRegion><wicri:noRegion>Neu-Isenburg</wicri:noRegion></affiliation></author><author><name sortKey="Rimm, David" sort="Rimm, David" uniqKey="Rimm D" first="David" last="Rimm">David Rimm</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Yale University School of Medicine, New Haven, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Yale University School of Medicine, New Haven</wicri:regionArea><wicri:noRegion>New Haven</wicri:noRegion></affiliation></author><author><name sortKey="Symmans, Fraser" sort="Symmans, Fraser" uniqKey="Symmans F" first="Fraser" last="Symmans">Fraser Symmans</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Texas M.D. Anderson Cancer Center, Houston</wicri:regionArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Denkert, Carsten" sort="Denkert, Carsten" uniqKey="Denkert C" first="Carsten" last="Denkert">Carsten Denkert</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Pathology, Charité Universitätsmedizin Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Adams, Sylvia" sort="Adams, Sylvia" uniqKey="Adams S" first="Sylvia" last="Adams">Sylvia Adams</name><affiliation wicri:level="2"><nlm:affiliation>New York University Medical School, Perlmutter Cancer Center, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York University Medical School, Perlmutter Cancer Center, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Loi, Sherene" sort="Loi, Sherene" uniqKey="Loi S" first="Sherene" last="Loi">Sherene Loi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Salgado, Roberto" sort="Salgado, Roberto" uniqKey="Salgado R" first="Roberto" last="Salgado">Roberto Salgado</name><affiliation wicri:level="1"><nlm:affiliation>Translational Breast Cancer Genomic and Therapeutics Laboratory, Peter Mac Callum Cancer Center, Victoria, Australia; Breast Cancer Translational Research Laboratory, Jules Bordet Institute, Brussels, Belgium; Department of Pathology, GZA, Antwerp, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Translational Breast Cancer Genomic and Therapeutics Laboratory, Peter Mac Callum Cancer Center, Victoria, Australia; Breast Cancer Translational Research Laboratory, Jules Bordet Institute, Brussels, Belgium; Department of Pathology, GZA, Antwerp</wicri:regionArea><wicri:noRegion>Antwerp</wicri:noRegion></affiliation></author></analytic><series><title level="j">Seminars in cancer biology</title><idno type="eISSN">1096-3650</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Morphological evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer is gaining momentum as evidence strengthens the clinical relevance of this immunological biomarker. TILs in the post-neoadjuvant residual disease setting are acquiring increasing importance as a stratifying marker in clinical trials, considering the raising interest on immunotherapeutic strategies after neoadjuvant chemotherapy. TILs in ductal carcinoma in situ, with or without invasive carcinoma, represent an emerging area of clinical breast cancer research. The aim of this report is to update pathologists, clinicians and researchers on TIL assessment in both the post-neoadjuvant residual disease and the ductal carcinoma in situ settings. The International Immuno-Oncology Working Group proposes a method for assessing TILs in these settings, based on the previously published International Guidelines on TIL Assessment in Breast Cancer. In this regard, these recommendations represent a consensus guidance for pathologists, aimed to achieve the highest possible consistency among future studies.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pérou</li><li>États-Unis</li></country><region><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li><li>Berlin</li><li>Communauté de Madrid</li><li>Lombardie</li><li>Maryland</li><li>Pennsylvanie</li><li>Région de Bruxelles-Capitale</li><li>Texas</li><li>Victoria (État)</li><li>État de New York</li></region><settlement><li>Berlin</li><li>Bruxelles</li><li>Clermont-Ferrand</li><li>Houston</li><li>Madrid</li><li>Melbourne</li><li>Milan</li></settlement><orgName><li>Université libre de Bruxelles</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="Dieci, Maria Vittoria" sort="Dieci, Maria Vittoria" uniqKey="Dieci M" first="Maria Vittoria" last="Dieci">Maria Vittoria Dieci</name></noRegion><name sortKey="Pruneri, Giancarlo" sort="Pruneri, Giancarlo" uniqKey="Pruneri G" first="Giancarlo" last="Pruneri">Giancarlo Pruneri</name><name sortKey="Viale, Giuseppe" sort="Viale, Giuseppe" uniqKey="Viale G" first="Giuseppe" last="Viale">Giuseppe Viale</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Radosevic Robin, Nina" sort="Radosevic Robin, Nina" uniqKey="Radosevic Robin N" first="Nina" last="Radosevic-Robin">Nina Radosevic-Robin</name></region><name sortKey="Michiels, Stefan" sort="Michiels, Stefan" uniqKey="Michiels S" first="Stefan" last="Michiels">Stefan Michiels</name><name sortKey="Penault Llorca, Frederique" sort="Penault Llorca, Frederique" uniqKey="Penault Llorca F" first="Frederique" last="Penault-Llorca">Frederique Penault-Llorca</name><name sortKey="Ternes, Nils" sort="Ternes, Nils" uniqKey="Ternes N" first="Nils" last="Ternes">Nils Ternes</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Fineberg, Susan" sort="Fineberg, Susan" uniqKey="Fineberg S" first="Susan" last="Fineberg">Susan Fineberg</name></region><name sortKey="Adams, Sylvia" sort="Adams, Sylvia" uniqKey="Adams S" first="Sylvia" last="Adams">Sylvia Adams</name><name sortKey="Badve, Sunil" sort="Badve, Sunil" uniqKey="Badve S" first="Sunil" last="Badve">Sunil Badve</name><name sortKey="Bossuyt, Veerle" sort="Bossuyt, Veerle" uniqKey="Bossuyt V" first="Veerle" last="Bossuyt">Veerle Bossuyt</name><name sortKey="D Alfonso, Timothy M" sort="D Alfonso, Timothy M" uniqKey="D Alfonso T" first="Timothy M" last="D'Alfonso">Timothy M. D'Alfonso</name><name sortKey="Demaria, Sandra" sort="Demaria, Sandra" uniqKey="Demaria S" first="Sandra" last="Demaria">Sandra Demaria</name><name sortKey="Hewitt, Stephen" sort="Hewitt, Stephen" uniqKey="Hewitt S" first="Stephen" last="Hewitt">Stephen Hewitt</name><name sortKey="Kim, Seong Rim" sort="Kim, Seong Rim" uniqKey="Kim S" first="Seong-Rim" last="Kim">Seong-Rim Kim</name><name sortKey="Rimm, David" sort="Rimm, David" uniqKey="Rimm D" first="David" last="Rimm">David Rimm</name><name sortKey="Singh, Baljit" sort="Singh, Baljit" uniqKey="Singh B" first="Baljit" last="Singh">Baljit Singh</name><name sortKey="Symmans, Fraser" sort="Symmans, Fraser" uniqKey="Symmans F" first="Fraser" last="Symmans">Fraser Symmans</name></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Van Den Eynden, Gert" sort="Van Den Eynden, Gert" uniqKey="Van Den Eynden G" first="Gert" last="Van Den Eynden">Gert Van Den Eynden</name></region><name sortKey="Salgado, Roberto" sort="Salgado, Roberto" uniqKey="Salgado R" first="Roberto" last="Salgado">Roberto Salgado</name></country><country name="Pérou"><noRegion><name sortKey="Castaneda, Carlos" sort="Castaneda, Carlos" uniqKey="Castaneda C" first="Carlos" last="Castaneda">Carlos Castaneda</name></noRegion><name sortKey="Sanchez, Joselyn" sort="Sanchez, Joselyn" uniqKey="Sanchez J" first="Joselyn" last="Sanchez">Joselyn Sanchez</name></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Rojo, Federico" sort="Rojo, Federico" uniqKey="Rojo F" first="Federico" last="Rojo">Federico Rojo</name></region></country><country name="Canada"><noRegion><name sortKey="Nielsen, Torsten" sort="Nielsen, Torsten" uniqKey="Nielsen T" first="Torsten" last="Nielsen">Torsten Nielsen</name></noRegion></country><country name="Allemagne"><noRegion><name sortKey="Wienert, Stephan" sort="Wienert, Stephan" uniqKey="Wienert S" first="Stephan" last="Wienert">Stephan Wienert</name></noRegion><name sortKey="Denkert, Carsten" sort="Denkert, Carsten" uniqKey="Denkert C" first="Carsten" last="Denkert">Carsten Denkert</name><name sortKey="Loibl, Sybille" sort="Loibl, Sybille" uniqKey="Loibl S" first="Sybille" last="Loibl">Sybille Loibl</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Loi, Sherene" sort="Loi, Sherene" uniqKey="Loi S" first="Sherene" last="Loi">Sherene Loi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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